Many cities are losing existing and potential businesses to their suburban counterparts. This is partly due to the fact that, in some places, doing business in the central city requires jumping over high regulatory and bureaucratic hurdles. This working paper will examine the factors driving corporate locational decisionmaking and the rise of corporate mobility and determine ways in which federal, state, and local governments can help create more business-friendly climates to better position cities as the location of choice for businesses. The policy recommendations will be valuable in helping both central cities and their suburbs adopt more competitive economic development strategies.