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Inflammatory Exposure and Historical Changes in Human Life-Spans

1. Caleb E. Finch*,
2. Eileen M. Crimmins

1. ↵* To whom correspondence should be addressed. E-mail: cefinch@usc.edu

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Science 17 Sep 2004:
Vol. 305, Issue 5691, pp. 1736-1739
DOI: 10.1126/science.1092556
Caleb E. Finch
Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA.

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Eileen M. Crimmins
Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA.

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## Abstract

Most explanations of the increase in life expectancy at older ages over history emphasize the importance of medical and public health factors of a particular historical period. We propose that the reduction in lifetime exposure to infectious diseases and other sources of inflammation—a cohort mechanism—has also made an important contribution to the historical decline in old-age mortality. Analysis of birth cohorts across the life-span since 1751 in Sweden reveals strong associations between early-age mortality and subsequent mortality in the same cohorts. We propose that a “cohort morbidity phenotype” represents inflammatory processes that persist from early age into adult life.

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### Science

Vol 305, Issue 5691
17 September 2004

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  ### Inflammation and Life-Span

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###
Inflammatory Exposure and Historical Changes in Human Life-Spans

By Caleb E. Finch, Eileen M. Crimmins

Science 17 Sep 2004 : 1736-1739

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